As you begin the program, we’d like to share some useful information on what to expect when starting your GLP-1 medication (glucagon-like peptide-1s).
How the medication works
GLP-1s are powerful, naturally-occurring hormones in your body that send signals to your brain to improve your metabolic function and regulate your appetite and digestion. The GLP-1 medications that Calibrate clinicians prescribe work on the same receptors as the natural GLP-1 hormones.
The GLP-1s you’ll be taking through Calibrate will help your body to fight the natural increases in appetite and hunger that occur as you begin to lose weight. GLP-1s are different from older classes of weight loss medications (like phentermine) because they work on key underlying metabolic pathways to support sustained weight loss and are not a quick fix.
How to take it
As for high-level things to keep in mind, Oral Wegovy has to be taken in a specific way to optimize absorption. Take it at least 30 minutes before your first food, beverage, or other oral medications of the day with no more than 4 ounces of plain water only.
Waiting less than 30 minutes, or taking it with food, beverages other than plain water, or other oral medications will lessen the effect of Oral Wegovy. Waiting more than 30 minutes to eat may increase the absorption of the medication. Tablets cannot be cut, crushed, or chewed. Oral Wegovy comes in a few different doses.
There are 4 doses: 1.5 mg, 4 mg, 9 mg, and 25mg daily. The Calibrate Clinical Team will initially send the 1.5 mg, 4 mg and 9 mg doses to your pharmacy. To help minimize side effects, you’ll begin with the lowest dose and taper up—start at 1.5 mg daily—for 30 days. After 30 days, increase to 4 mg daily. After 30 days, increase to 9 mg daily and remain on this dose. Finally, if additional medication support is necessary after 30 or more days at 9 mg, the dosage may be increased to the maximum of 25 mg per day.
One more quick tip: Oral Wegovy packaging might be challenging to open, partly because of a white plastic band underneath the cap that keeps the security seal in place. We suggest removing this band to make it easier to remove the cap.
What to expect
If you experience intolerable side effects after a dose increase, please message your clinical team via the Support Center in your Calibrate app. You may simply need to go back to the previous dose for another month or two prior to increasing the dose again, and your clinician will advise you on the best course of action based on your specific needs.
Side effects typically go away with time (usually by 3-4 weeks) so try to stick with it, if you can. If you have severe abdominal pain (which is very uncommon), please let us know right away via the Support Center in your app.
The most common side effects include nausea, constipation, diarrhea, and stomach discomfort. In case of an emergency (such as severe abdominal pain) please call 911 or go to your nearest emergency room. If you experience a medical emergency, when you are able to do so, please also notify your Calibrate Clinical Team in your Calibrate app.
If you would like to learn more about your medication, please visit this page, and if you have any further questions about how to take your medicine, please message your clinical team via the Support Center in your app and we’ll be glad to help.
How do GLP-1 medications work?
GLP-1 (glucagon-like peptide 1) is a hormone naturally produced by your small intestine. GLP-1 medications work on the same receptors as your natural GLP-1 hormone to control feelings of hunger and fullness and regulate blood sugar. Mechanistically, GLP-1s address biology in a way that helps lower your weight set point.
What are common side effects?
Many individuals don’t have any side effects with this medication. However, for those who do, nausea is the most common. Usually nausea resolves after a few weeks as your body adapts to medication, but we encourage you to reach out to the Medical Team to discuss dosage modifications and for side effect management. Do not increase the dose faster than recommended, since the dosing schedule was designed to minimize side effects. Things that help reduce nausea are eating blander foods, eating smaller meals, and staying active.
You may also have changes in bowel movements (constipation being the most common). If this happens, you can take a fiber supplement (such as Metamucil or Benefiber) or increase your intake of vegetables and fruits.
If you’re worried about any side effects, you can also always message the Medical Team through the Support Center in the Calibrate app.
How long does it take for the medication to work?
It usually takes a couple of weeks of titrating up on the medication before you start losing weight, but you may notice that you feel full longer within the first week.
What if I forgot to take it one day?
If you miss a dose of Oral Wegovy, restart it as soon as you remember and continue taking it daily as prescribed.
If you experience a lapse in Oral Wegovy for more than 3 days, please send the medical team a message for guidance on restarting your medication as dosage adjustments might be needed.
Is there a risk of developing thyroid cancer?
We do not recommend GLP-1s if you have a personal or family history of medullary thyroid cancer or MEN syndrome. But for everyone else, there are no human studies that show an increased risk of thyroid cancer.